Author: Admin
The concept of targeted protein degradation (TPD) was proposed in 1999 [1]. Two years later, the first proteolysis-targeting chimeras (PROTAC) demonstrated selective synthetic molecule-mediated protein removal inside cells selectively [2]. Unlike occupancy-driven inhibitors, TPD eliminates “undruggable” proteins by directing the proteins of interest (POI) to cellular degradation machinery, including the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (Fig. 1A) [3], [4]. A typical TPD platform comprises a POI-binding ligand, an effector (e.g., E3 ligase) recruiter, and a chemical linker [5]. The induced proximity between POI and effector triggers efficient POI degradation [6].PROTACs, first entered clinical trials in 2019 (ARV-110/471) [7], rely…
There are many let’s encrypt automatic tools for azure but I also wanted to see if I could use certbot in wsl to generate a wildcard certificate for the azure Friday website and then upload the resulting certificates to azure app service. Azure app service ultimately needs a specific format called dot PFX that includes the full certificate path and all intermediates. Per the docs, App Service private certificates must meet the following requirements: Exported as a password-protected PFX file, encrypted using triple DES. Contains private key at least 2048 bits long Contains all intermediate certificates and the…
Jennings Anderson, a Software Engineer with Meta Platforms, and Amy Rose, the Chief Technology Officer at Overture Maps Foundation, speak with host Gregory M. Kapfhammer about the Overture Maps project, which creates reliable, easy-to-use, and interoperable open map data. After exploring the foundations of geospatial information systems, Gregory and his guests dive deep into the implementation of Overture Maps through features like the Global Entity Reference System (GERS). In addition to discussing the organizational structure of the Overture Maps Foundation and the need for a unified database of geospatial data, Jennings and Amy explain how to implement applications using data…
When it comes to price, the fact you can pick up the same machine I tested for $1,799 makes these Macs an absolute steal. Yes, I know that amount isn’t peanuts, it’s a lot of money – more than I can afford on the ever-shrinking pittance I make in journalism. But if you’re a professional user doing professional tasks that require this much horsepower, the price seems plenty attractive. Given that the Mac consistently delivers significantly higher Geekbench test results than its PC brethren, Windows laptops with Snapdragon X Elite and Intel Core Ultra 7 200 processors can’t match these…
Press Release [MUNICH, Germany] – [November 11, 2025] – Total Telecom, the organiser of Europe’s leading digital economy conferences, is pleased to announce the full agenda for Connected Germany 2025, taking place on November 18th and 19th at the MOC – Event Center Messe München. The two-day event will unite over 1,500 industry executives, policymakers, and innovators to accelerate the adoption of the latest digital technologies, from fibre and 5G to AI. The conference is set to tackle Germany’s most pressing connectivity challenges, with a deep focus on public-private partnerships, accelerating FTTH deployment, and securing digital sovereignty. Tackling Germany’s largest…
We are thrilled to introduce keras3, the next version of the Keras R package. keras3 is a ground-up rebuild of {keras}, maintaining the beloved features of the original while refining and simplifying the API based on valuable insights gathered over the past few years. Keras provides a complete toolkit for building deep learning models in R—it’s never been easier to build, train, evaluate, and deploy deep learning models. Installation To install Keras 3: install.packages(“keras3”) library(keras3) install_keras() What’s new: Documentation Great documentation is essential, and we’ve worked hard to make sure that keras3 has excellent documentation, both now, and in the…
GPT 5.1 is here. OpenAI is calling it the next big step, and honestly, it feels like one. When GPT-5 came out, people were amazed by its power but not everyone was happy. They removed the o-series models that many users loved for complex reasoning tasks. That move didn’t sit well. Now with GPT-5.1, OpenAI seems to have listened. The update brings back that same deep-thinking ability, only smarter and faster. It’s quick with simple tasks, thoughtful with complex ones, and a lot more natural in how it responds. GPT-5.1 feels less like a tech upgrade and more like a…
Today, I’m happy to announce a new capability to resolve location data for Amazon Sidewalk enabled devices with the AWS IoT Core Device Location service. This feature removes the requirement to install GPS modules in a Sidewalk device and also simplifies the developer experience of resolving location data. Devices powered by small coin cell batteries, such as smart home sensor trackers, use Sidewalk to connect. Supporting built-in GPS modules for products that move around is not only expensive, it can creates challenge in ensuring optimal battery life performance and longevity. With this launch, Internet of Things (IoT) device manufacturers and…
You’ve seen the videos: a too-perfect Taylor Swift promoting free cookware. A fake Tom Hanks offering dental insurance. They look real—but they’re not. New research from McAfee Labs shows just how common these scams have become. Our 2025 Most Dangerous Celebrity: Deepfake Deception List ranks the stars and influencers whose likenesses are most hijacked by scammers, and reveals a growing market for AI-powered fake endorsements. At the top of the list? Taylor Swift, followed by Scarlett Johansson, Jenna Ortega, and Sydney Sweeney. Globally, names like Brad Pitt, Billie Eilish, and Emma Watson also appear among the most exploited. McAfee also…
Information Resources for the Cleantech Sector in a Shifting Federal Landscape Shannon Bresnahan | Uncategorized Federal funding cuts, newly imposed taxes and tariffs, rollbacks of climate policies and renewable energy goals, and a cascade of executive orders and proposed legislation continue to create uncertainty for the cleantech sector. Please find below a number of relevant resources available to help keep the cleantech community informed in a shifting federal landscape. If you or your company have resources to share, please let us know. UPCOMING WEBINARS: Navigating the New Clean Energy Tax Landscape: Safe Harbor Rules, FEOC Compliance & Strategic…