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CpG oligodeoxynucleotides (CpG ODNs) are well-known adjuvants that induce innate immunity, particularly dendritic cell activation, by stimulating Toll-like receptor 9. However, the stimulatory efficacy of CpG ODNs is limited by their negative charge, which causes electrostatic repulsion from the cell membrane and hinders cellular uptake. In addition, CpG ODNs are rapidly degraded by nucleases under physiological conditions. To address these challenges, various nanoparticle (NP)-based delivery systems have been developed and applied across biomedical fields. Although various types of NPs have been utilized, the relationship between their physical properties and CpG delivery efficiency remains under investigation. In this study, we selected…

Mac Tahoe (in Beta as of the time of this writing) has this new feature called Edge Light that basically puts a bright picture of an Edge Light around your screen and basically uses the power of OLED to give you a virtual ring light. So I was like, why can’t we also have nice things? I wrote (vibed, with GitHub Copilot and Claude Sonnet 4.5) a Windows Edge Light App (source code at and you can get the latest release here /releases or the app will check for new releases and autoupdate with Updatum). However, as is…

Risk has many dimensions, and different stakeholders have different threat models and risk appetites. Cybersecurity risk is no exception. For example, a vulnerability in a software library could be critical to your operations if you are using the component of the library in which the vulnerability resides, but barely relevant if you are not. The Stakeholder-Specific Vulnerability Categorization (SSVC) methodology is a framework for different stakeholders to prioritize vulnerabilities according to their distinct risk appetites. Unlike other vulnerability categorization systems that rate on technical severity (impact on operations should the vulnerability to be exploited) or exploitability (how likely it is…

Donating money isn’t the only way you can help people. You can also give your blood.Of the approximately 62 percent of Americans eligible to donate blood, only 3 percent do so each year. But someone needs blood every few seconds in the US. While the average red blood cell transfusion is about three units, a single car accident victim can need up to 100 units of blood.Very few people eligible to donate blood do so each year. The need for blood is even greater around the holiday season. Blood has a limited shelf life and is used for many medical…

Artificial Intelligence (AI) is shifting from tools that predict to agents that act. That change doesn’t simply add new software to the stack; it rewires how decisions get made, how work flows across teams, and how value is created.   In that world, the Chief Information Officer (CIO) is not a buyer of platforms or a keeper of uptime, instead the CIO – the Chief Intelligence Orchestrator, designs how human expertise and autonomous agents learn from each other, supervise each other, and compound value together.  Yes, business units are more involved than ever in technology buying, especially in AI. That’s healthy, demand is closest to the problem. But the center of gravity still sits with the CIO, because only the CIO…

× Predicting Ego-centric Video from human Actions (PEVA). Given past video frames and an action specifying a desired change in 3D pose, PEVA predicts the next video frame. Our results show that, given the first frame and a sequence of actions, our model can generate videos of atomic actions (a), simulate counterfactuals (b), and support long video generation (c). Recent years have brought significant advances in world models that learn to simulate future outcomes for planning and control. From intuitive physics to multi-step video prediction, these models have grown increasingly powerful and expressive. But few are designed for truly embodied…

One of the things that we have talked a lot about at Smart Data Collective is how advanced degrees still matter in a world filled with automated tools and predictive systems. You can find many examples of professionals who feel uncertain about the future of their careers as AI moves into core functions, and it is common to see people question whether higher education still offers an advantage.A study by Anthony Cardillo at Exploding Topics reports that 78% of global companies are using AI in their daily operations, and you can see how this rapid spread raises questions about long-term…

Today, we’re announcing Amazon Route 53 Accelerated recovery for managing public DNS records, a new Domain Name Service (DNS) business continuity feature that is designed to provide a 60-minute recovery time objective (RTO) during service disruptions in the US East (N. Virginia) AWS Region. This enhancement ensures that customers can continue making DNS changes and provisioning infrastructure even during regional outages, providing greater predictability and resilience for mission-critical applications. Customers running applications that require business continuity have told us they need additional DNS resilience capabilities to meet their business continuity requirements and regulatory compliance obligations. While AWS maintains exceptional availability…

Co-authored by Alice Sanchez, Co-Lead, Native American Network (NAN); Josh Hammonds, Co-Lead, Native American Network (NAN) We are living in a pivotal moment for Tribal Nations. The scale of federal investment—driven by landmark legislation and new policy priorities—is the largest seen in modern history. This moment brings extraordinary progress and promise, but also a deeper need: trusted partners who show up with respect, expertise, and a spirit of service. This is more than a policy shift; it’s a relationship opportunity. At Cisco, we’re called to demonstrate, in our actions and our approach, exactly who we say we are—by leading with…

Cleantech San Diego Wins Wells Fargo IN2 Strategic Award to Pilot Voucher Program for Startups On April 8, 2025, the Wells Fargo Innovation Incubator (IN2), an energy technology program funded by Wells Fargo and co-administered by the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL), announced that Cleantech San Diego is among its 2025 Channel Partner Strategic Award winners. With $1 million in funding, this year’s awards support seven national projects, focusing on commercialization and pilot opportunities to drive advanced energy innovation.   The selection committee evaluated applications based on the potential for capacity building, regional collaboration, knowledge-sharing, and action-oriented initiatives…