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Peptide nanofibrils (PNFs) are gaining attention as promising transduction enhancers to improve viral vector delivery in ex vivo gene therapy applications. However, the influence of PNF structural morphology on viral capture and cellular interaction remains poorly understood. Here, we systematically compare two clinically relevant PNFs, D4, a short β-sheet-forming peptide, and Vectofusin-1, an α-helical peptide, focusing on their fibrillar architecture, viral particle binding, and interaction with host cells. Secondary structure analysis, molecular dynamics simulations and electron microscopy revealed that D4 forms loosely packed, β-sheet-rich aggregates, while Vectofusin-1 assembles into compact, α-helical structures. Both superstructures have a positive and hydrophobic surface…

We’ve been having conversations for thousands of years. Whether to convey information, conduct transactions, or simply to check in on one another, people have yammered away, chattering and gesticulating, through spoken conversation for countless generations. Only in the last few millennia have we begun to commit our conversations to writing, and only in the last few decades have we begun to outsource them to the computer, a machine that shows much more affinity for written correspondence than for the slangy vagaries of spoken language. Article Continues Below Computers have trouble because between spoken and written language, speech is more primordial.…

AI agents have taken on a growing share of software development work, so much so that the hardest problems are shifting away from code generation towards something new, context. The challenge is now contextualizing why systems work the way they do, how architectural decisions were made, and the sources of truth that exist outside of the code base. As teams adopt agentic tools, gaps or inconsistencies in context have emerged as a primary reason why software fails to meet production standards. Unblocked is a startup focused on solving this context gap. Their context engine aggregates and reasons over organizational knowledge…

Dario Amodei said Thursday that Anthropic plans to challenge the Department of Defense’s decision to label the AI firm a supply-chain risk in court, a designation he has called “legally unsound.” The statement comes a few hours after the DOD officially designated Anthropic a supply-chain risk following a weeks-long dispute over how much control the military should have over AI systems. A supply-chain risk designation can bar a company from working with the Pentagon and its contractors. Amodei drew a firm line that Anthropic’s AI will not be used for mass surveillance of Americans or for fully autonomous weapons, but…

Core banking transformation has entered a new phase. What was once dominated by long, high-risk replacement programs is now shaped by incremental modernization, coexistence strategies, and embedded intelligence. Banks are no longer debating whether their cores need to evolve, the focus has shifted decisively to how to modernize without disrupting stability, compliance, or daily operations.  Everest Group’s Top 50™ Core Banking Technology Providers 2026 research captures this shift, reflecting a market that is both expanding and fundamentally redefining its priorities.  A growing market and a growing imperative  The global core banking technology market is estimated at US$13–14 billion in 2025 and is expected to reach US$23–24…

Press Release Huawei released a series of all-scenario U6 GHz products today at MWC Barcelona 2026 to help carriers unlock the full potential of 5G-A and set the stage for a seamless transition to 6G. The company also launched enhanced AI-Centric Network solutions that will help carriers prepare for the agentic era by enabling intelligent services, networks, and network elements (NEs). Huawei is also showcasing its SuperPoD cluster for the first time outside China, which they have created to offer “a new option for the intelligent world”. The theme of Huawei’s booth for this year’s conference is “Advancing All Intelligence”,…

This is the first article in a series on agentic engineering and AI-driven development. Look for the next article on March 19 on O’Reilly Radar.There’s been a lot of hype about AI and software development, and it comes in two flavors. One says, “We’re all doomed, that tools like Claude Code will make software engineering obsolete within a year.” The other says, “Don’t worry, everything’s fine, AI is just another tool in the toolbox.” Neither is honest.I’ve spent over 20 years writing about software development for practitioners, covering everything from coding and architecture to project management and team dynamics. For…

This is a guest post by Jeffrey Wang, Co-Founder and Chief Architect at Amplitude in partnership with AWS. Amplitude is a product and customer journey analytics platform. Our customers wanted to ask deep questions about their product usage. Ask Amplitude is an AI assistant that uses large language models (LLMs). It combines schema search and content search to provide a customized, accurate, low latency, natural language-based visualization experience to end customers. Ask Amplitude has knowledge of a user’s product, taxonomy, and language to frame an analysis. It uses a series of LLM prompts to convert the user’s question into a…

Samsung moved artificial intelligence closer to live telecom infrastructure at MWC 2026, where it demonstrated AI running alongside radio functions inside a cloud-native network stack.At MWC in Barcelona, Samsung Electronics showcased an AI-native, software-driven network architecture built around its virtualised radio access network (vRAN) platform. Samsung integrated its vRAN software with accelerated computing from NVIDIA, combining Samsung’s cloud-native RAN stack with NVIDIA’s Grace CPU and L4 GPU platform.The demonstration focused on showing how AI workloads could operate within a multi-cell test environment that simulated real network conditions. According to Samsung, the setup was designed to support AI-based signal processing and…

Embracing connectivity, automation, and innovation across vendors. February is the month of love and friendship. At Cisco DevNet, we used that spirit as inspiration to celebrate something we care deeply about: building meaningful connections across the networking ecosystem. The Month of Smart Connections campaign explored how automation and programmability can bring different vendors together through open standards, shared tooling, and practical workflows. Across four videos, each paired with its own code repository, we showcased vendor-agnostic approaches to network automation. From scripting fundamentals to agentic AI workflows, the Month of Smart Connections delivered practical ideas to help you start or strengthen…