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Aletaha, D. & Smolen, J. S. Diagnosis and management of rheumatoid arthritis: a review. JAMA 320, 1360–1372 (2018).Article  PubMed  Google Scholar  Gravallese, E. M. & Firestein, G. S. Rheumatoid arthritis—common origins, divergent mechanisms. N. Engl. J. Med. 388, 529–542 (2023).Article  CAS  PubMed  Google Scholar  Zhang, F. et al. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature 623, 616–624 (2023).Article  CAS  PubMed  PubMed Central  Google Scholar  Fearon, U., Hanlon, M. M., Floudas, A. & Veale, D. J. Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications. Nat. Rev. Rheumatol. 18, 398–414 (2022).Article  CAS  PubMed  Google Scholar  Buckley, C. D.,…

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Python’s popularity in data science and backend engineering has made it the default language for building AI infrastructure. However, with the rapid growth of AI applications, developers are increasingly looking for tools that combine Python’s flexibility with the rigor of production-ready systems. Pydantic began as a library for type-safe data validation in Python and has become one of the language’s most widely adopted projects. More recently, the Pydantic team created Pydantic AI, a type-safe agent framework for building reliable AI systems in Python. Samuel Colvin is the creator of Pydantic and Pydantic AI. In this episode, he joins the podcast…

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When to watch Aston Villa vs. ArsenalSaturday, Dec. 6, at 7:30 a.m. ET (4:30 a.m. PT).Where to watchAston Villa vs. Arsenal will air in the US on USA Network. See at Sling TV Watch the Premier League on USA Network from $46 a month Sling Blue 73% off with 2yr plan (+4 free months). Now only $3.49/month See more details See at TNT Sport Watch over 50 Premier League games live in the UK with TNT Sports TNT Sports See at Fubo Watch the Premier League in Canada Fubo Canada See at Stan Sport Watch every Premier League match live…

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The first full trailer for A Knight of the Seven Kingdoms is here, and unveils a surprising quest in the world created by George R.R. Martin. Although the clip features proud aristocrats and brutal duels in a typical Game of Thrones fashion, it promises a buddy comedy-style story. A tagline, “A Journey Far From the Throne”, also suggests a more personal story. The new HBO series is set between the events of House of the Dragon and Game of Thrones. The plot focuses on the adventures of Ser Duncan the Tall and his young squire, Egg, rather than the history…

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The best way to ensure broadband networks are performing as promised and public investments are paying off is to keep a finger on the pulse Between 2011 and 2023, the Federal Communications Commission (FCC) ran an in-home broadband measurement program called Measuring Broadband America (MBA). The campaign enlisted thousands of volunteers to take direct measurements of fixed broadband service performances of some of the largest service providers in the country using at-home test kits. The data collected fed into periodic reports that laid out the performance levels demonstrated by each provider under specific test conditions.  The primary objective of this…

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Artificial intelligence took over as the star at Google I/O 2025, showcasing some of the best tech solutions from the company. Google continues to aim for leadership in AI by showing off more than 100 AI-enabled updates across its products at one time.  From improved language technology to video creation tools and from real-time fraud detection to AI helpers, these announcements highlight a fresh and exciting time for Google’s products and services. This year’s event wasn’t just about incremental upgrades. It was about redefining what AI can do in our daily lives, work, and creative endeavors. Let’s review the top…

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Driving Data Trust, Quality, and Governance with AtlanThe Active Metadata Pioneers series features Atlan customers who have completed a thorough evaluation of the Active Metadata Management market. Paying forward what you’ve learned to the next data leader is the true spirit of the Atlan community! So they’re here to share their hard-earned perspective on an evolving market, what makes up their modern data stack, innovative use cases for metadata, and more.In this installment of the series, we meet Kenza Zanzouri, Technical Governance Expert at Contentsquare, a leading digital experience analytics platform that provides rich context and insights into behavior, feelings,…

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It’s a foggy morning in Munich. Marie, CIO of a fictional, forward-thinking European healthcare startup, pores over proposals from cloud vendors. Her company is on the verge of launching AI-powered diagnostics but must keep every byte of patient data within EU borders to comply with strict regional privacy laws. On her desk are slick portfolios from Microsoft, AWS, and Google, all touting sovereign cloud options in the EU. Alongside them are proposals from national cloud providers—smaller, perhaps, but wholly grounded in local laws and run by European nationals. After consulting several legal teams, Marie chooses the local sovereign cloud, believing…

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The U.S. Cybersecurity and Infrastructure Security Agency (CISA) on Thursday released details of a backdoor named BRICKSTORM that has been put to use by state-sponsored threat actors from the People’s Republic of China (PRC) to maintain long-term persistence on compromised systems. “BRICKSTORM is a sophisticated backdoor for VMware vSphere and Windows environments,” the agency said. “BRICKSTORM enables cyber threat actors to maintain stealthy access and provides capabilities for initiation, persistence, and secure command-and-control.” Written in Golang, the custom implant essentially gives bad actors interactive shell access on the system and allows them to browse, upload, download, create, delete, and manipulate…

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Ice melt salt does more for winter safety than most people think. Winter can look calm and beautiful, but it can also turn roads and walkways into slick, dangerous surfaces fast. A sudden cold front can make streets feel like glass and sidewalks feel unsafe. Snowplows and grit trucks play their part, but ice melt salt does the quiet, steady work. This small mineral helps break the bond between ice and the ground, making it easier for people and cars to move safely. From small driveways to big highways, ice melt salt is used everywhere. But there is more to…

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