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Deng, R. et al. Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis. Sci. Transl. Med. 16, eadh9751 (2024).Article  CAS  PubMed  Google Scholar  Zhou, D. et al. Intra-articular nanodrug delivery strategies for treating osteoarthritis. Drug Discov. Today 28, 103482 (2022).Article  PubMed  Google Scholar  Jones, I. A., Togashi, R., Wilson, M. L., Heckmann, N. & Vangsness, C. T. Jr Intra-articular treatment options for knee osteoarthritis. Nat. Rev. Rheumatol. 15, 77–90 (2019).Article  PubMed  PubMed Central  Google Scholar  Bedingfield, S. K. et al. Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage.…

I listen to a lot of music, it’s a constant accompaniment to my work and our evening relaxing. I don’t use streaming services, every couple of weeks I buy a bunch of digital albums and listen to them every day until we’re ready for a new batch. Here’s my favorite six from last year’s listening. I’ve long been a fan of the explosive brass from Balkan wedding bands, and Fanfare Ciocărlia are a prime example of the style. This is energetic blowing from a tight band that gets the adrenaline flowing. On this album they combine with Canadian jazz-rock guitarist…

Modern software development is more complex than ever. Teams work across different operating systems, chip architectures, and cloud environments, each with its own dependency quirks and version mismatches. Ensuring that code runs reproducibly across these environments has become a major challenge that’s made even harder by growing concerns around software supply chain security. Nix is a powerful open-source package manager that builds software in controlled, declarative environments where dependencies are explicitly defined and reproducible. Its functional approach has made it a gold standard for reproducible builds, but it can also be difficult to learn and adopt. Flox is a company…

This story appeared in Today, Explained, a daily newsletter that helps you understand the most compelling news and stories of the day. Subscribe here.The video opens with a question and a slamming door. Nick Shirley, the 23-year-old right-wing content creator who rose to sudden infamy and influence last week, confronts two Somali women as the camera rolls.“Hello, we’d like to ask where the money is going,” Shirley says as the women scramble away. It’s a scene that repeats again and again throughout his wildly viral 43-minute video — published to YouTube on December 26 — that purports to “investigate” widespread…

EHS International, a leading provider of environmental, health, and safety (EHS) services with offices in Cork, Dublin, Belfast and London, has launched new certified training courses in construction safety. Fully accredited by the Institution of Occupational Safety and Health (IOSH), the courses cover both Project Supervisor Design Process (PSDP) and Project Supervisor Construction Stage (PSCS). Designed for professionals overseeing safety during the design and build phases, the training supports compliance with the?Safety, Health and Welfare at Work (Construction) Regulations 2013. Courses are led by experienced EHS International trainers and are available both in person and via live, instructor-led webinars. Speaking on the new training courses, Derry…

If you lead an enterprise data science team or a quantitative research unit today, you likely feel like you are living in two parallel universes. In one universe, you have the “GenAI” explosion. Chatbots now write code and create art, and boardrooms are obsessed with how large language models (LLMs) will change the world. In the other universe, you have your day job: the “serious” work of predicting churn, forecasting demand, and detecting fraud using structured, tabular data.  For years, these two universes have felt completely separate. You might even feel that the GenAI hype rocketship has left your core…

How Modern Data Platforms Are Transforming Cybersecurity Operations in Critical InfrastructureThe Energy & Utilities (E&U) sector faces unprecedented cybersecurity challenges as operational technology (OT) and information technology (IT) systems converge, creating new vulnerabilities that threat actors are aggressively exploiting. With ransomware attacks on OT/ICS systems surging by 87% in 2024 1 and third-party breaches driving 45% of all security incidents in the energy sector 2 , traditional SIEM solutions are proving inadequate for the scale and complexity of modern security operations.The solution lies in adopting a unified data platform approach that can handle the massive volumes of security telemetry from…

Happy New Year! I hope the holidays gave you time to recharge and spend time with your loved ones. Like every year, I took a few weeks off after AWS re:Invent to rest and plan ahead. I used some of that downtime to plan the next cohort for Become a Solutions Architect (BeSA). BeSA is a free mentoring program that I, along with a few other Amazon Web Services (AWS) employees, volunteer to host as a way to help people excel in their cloud and AI careers. We’re kicking off a 6-week cohort on “Agentic AI on AWS” starting February…

To address this gap and help the ecosystem with deploying robust defenses, Google has supported academic research and developed test platforms to analyze DDR5 memory. Our effort has led to the discovery of new attacks and a deeper understanding of Rowhammer on the current DRAM modules, helping to forge the way for further, stronger mitigations.What is Rowhammer? Rowhammer exploits a vulnerability in DRAM. DRAM cells store data as electrical charges, but these electric charges leak over time, causing data corruption. To prevent data loss, the memory controller periodically refreshes the cells. However, if a cell discharges before the refresh cycle, its…

The program addresses the urgent problem of storing excess electricity generated on windy or sunny days, to make it available when demand exceeds supply. A new research collaboration aims to develop GPStore, a pioneering long-duration energy storage technology that could play a vital role in supporting the UK’s transition to net zero. The project, led by Professor Yasser Mahmoudi Larimi from The University of Manchester, has been awarded a £3 million EPSRC Critical Mass Programme Grant. It brings together expertise from industry and academia across the UK, which also includes the University of Birmingham, the University of Liverpool, Cranfield University…