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Extracellular vesicles (EVs) are naturally secreted, non-nuclear lipid nanostructures by biological sources with intrinsic features such as biocompatibility, low immunogenicity, and the ability to bypass biological barriers. Despite the growing interest in EV research, their biological potential as a versatile drug delivery vehicle has yet to be widely translated for clinical use. Fewer than 3 % of clinical trials involving these cell-free vesicles have utilized them for drug delivery applications. This review elucidates the reasons behind the translational gap through a comprehensive analysis of pharmacokinetic and tissue transport challenges faced by EVs across various tissue barriers, including the cartilage, blood-brain interface,…
Software development has always resisted the idea that it can be turned into an assembly line. Even as our tools become smarter, faster, and more capable, the essential act remains the same: we learn by doing. An Assembly Line is a poor metaphor for software development In most mature engineering disciplines, the process is clear: a few experts design the system, and less specialized workers execute the plan. This separation between design and implementation depends on stable, predictable laws of physics and repeatable patterns of construction. Software doesn’t work like that. There are repetitive parts that can be automated, yes,…
The modern internet is a vast web of independent networks bound together by billions of routing decisions made every second. It’s an architecture so reliable we mostly take it for granted, but behind the scenes it represents one of humanity’s greatest engineering achievements. Today’s internet is also dramatically more complex and capable than in its early years. Erik Seidel is a Network Engineer at Cloudflare, where he focuses on automating global network infrastructure. He joins the show to discuss his unique journey into tech, the fundamentals of how the internet works, the Border Gateway Protocol, peering versus transit, Cloudflare’s architecture,…
Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.Need some help with today’s Mini Crossword? There’s a game in there that I have never heard of before. If you want the answers, read on. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.Read more: Tips and Tricks for…
Hunted is arguably one of the most intense reality shows in the UK (a far cry from Bake Off), requiring both physical stamina and emotional resilience as fugitives evade capture from ex-police and military professionals for three weeks. Nobody knows that better than the winner of series 8, which concluded on Monday. In an interview with Tech Advisor, they reveal just what you need to do to avoid being caught. Spoilers for Hunted series 8 below Shaq’s journey got off to a slightly rocky start. Along with his brother-in-law, Warren, the pair managed to break out of Stansted Airport. However, they first relied on their own home network, which meant that Chief Ray and…
What lessons can be learned from Microsoft’s cloud transformation? Editor’s note: This is the first part of a three-part series co-authored by Jim Brisimitzis and Chetan Sharma, exploring the nexus of the cloud/AI and telecom industries from an industry lens. Their decades of experience in the industry and in innovation give us a unique perspective on the lessons we’ve learned and how they can be transferable. The story of Microsoft’s transformation is a powerful lesson for all industries, and for Telcos in particular. In the mid-2000s, Microsoft was a behemoth of on-premises software with billions of dollars in revenue tied…
Across industries, a new type of employee is emerging: the digital coworker. AI agents that collaborate, learn, and make decisions are changing how enterprise teams operate and grow. These aren’t like the static chatbots or RPA scripts running in the background. They’re autonomous agents that act as colleagues — not code — helping teams move faster, make smarter decisions, and scale institutional knowledge. Managers are now learning to hire, onboard, and supervise AI agents like human employees, while teams are redefining trust, learning how to share context, and reshaping collaboration around intelligent systems that can act independently. For leaders, this…
Key Takeaways Learn how to overcome the limitations of legacy on-premises infrastructure and accelerate modernization. Discover FAQs and best practices for reducing migration risk, improving agility, and future-proofing customer engagement. Understand how EngageOne cloud migration enables scalability, continuous innovation, and alignment with enterprise cloud strategies. Explore proven methods to reduce total cost of ownership (TCO), strengthen resilience, and deliver seamless communications at scale. The Modernization Imperative: Why On-Premise Is Holding Enterprises Back For years, on-premises deployments of customer communication platforms like EngageOne have powered critical interactions between brands and their customers. But today, many organizations find these environments increasingly difficult…
When I first started working with multi-agent collaboration (MAC) systems, they felt like something out of science fiction. It’s a group of autonomous digital entities that negotiate, share context, and solve problems together. Over the past year, MAC has begun to take practical shape, with applications in multiple real-world problems, including climate-adaptive agriculture, supply chain management, and disaster management. It’s slowly emerging as one of the most promising architectural patterns for addressing complex and distributed challenges in the real world. In simple terms, MAC systems consist of multiple intelligent agents, each designed to perform specific tasks, that coordinate through shared…
At Cisco Partner Summit 2025, we announced the winners of Cisco’s eighth annual Global Partner Innovation Challenge, and this year proved something we’ve long believed: when you give brilliant partners an open platform and real customer challenges to solve, they don’t just meet the moment. They redefine what’s possible. With $1 million USD in prizes and a record-breaking 40 percent increase in submissions from 26 countries, this year’s challenge demonstrated that our partner ecosystem isn’t just adopting AI. They’re leading with it. The results? Students get mental health support before a crisis hits. Wasted renewable energy powers AI workloads. Returned…